As Amanda tries to leave the car to help her, the snake reappears and devours Sofia. The car crashes and Sofia is thrown from the car, breaking her leg in the process. During the next confrontation with the snake, the anaconda spits acidic venom in Victor's face, burning it. As the group splits up, Amanda heads off in a car with two other team members, Victor and Sofia.
Hammett arrives and gives the team a lecture on how to kill the snake. During the first confrontation with the snake, two of the party are killed: Grozny is stabbed by the genetically altered anaconda's very sharp tail and Dragosh gets his head bitten off by the snake. The hunting party arrives later and begin formulating a plan of attack. At a small farm in the middle of the woods, the owner is eaten alive by one of the snakes. Murdoch calls in a team of animal hunters, led by Stephen Hammett to capture both snakes. The anaconda soon sneaks up behind them and crushes the professor to death in its coils and bites his head off. In looking through the facility, Amanda and the professor realize that the anaconda also freed the queen anaconda. As it escapes, it kills many of the people working in the laboratory.
However, as Murdoch, his assistant Pinkus and Daryl are about to leave, the anaconda kills Daryl and breaks through the enclosure's wall. While visiting the facility, Murdoch provokes the anaconda with a large flashlight, and has it gassed to calm it down. Amanda Hayes and funded by Peter "J.D." Murdoch, a well-known industrialist. In Romania, an anaconda that was captured from the Amazon River is being held at a genetic research facility owned by Wexel Hall for experimentation where Professor Eric Kane has developed a serum for the Blood Orchid (the one recovered from the fountain after the ruins of the Borneo jungle).
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